Gong, Y., and Hewett, J.A. “Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.” Neuroscience. S0306-4522(18) 20020-4, 2018


Hewett, S.J., Shi, J., Gong, Y., Dhandapani, K., Pilbeam, C., and Hewett, J.A. “Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCTRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).” J. Biol. Chem. 291(53):27279-27288, 2016


Uliasz, T.F., Hamby, M.E., Jackman, N.A., Hewett, J.A., and Hewett, S.J. “Generation of primary astrocyte cultures devoid of contaminating microglia.” Methods Mol. Biol. 814: 61-79, 2012

Hewett J.A. and Hewett S.J. “Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures.” Methods Mol. Biol. 814: 251-263, 2012.

Claycomb, R.J., Hewett, S.J., and Hewett, J.A. “Anticonvulsant properties of endogenous interleukin-1β: possible contribution of cyclooxygenase-2.” Neurobiol. Dis., 45:234-42, 2012.


Claycomb, R.J., Hewett, S.J., and Hewett, J.A. “Characterization of the effect of oral rofecoxib treatment on PTZ-induced acute seizures and kindling.” Epilepsia 52:273-283, 2011.


Hamby, M.E., Hewett, J.A., and Hewett, S.J. “Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression.” Glia 58:1282-1291, 2010.


Hewett, J.A. “Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system.” J. Neurochem. 110:1717-1736, 2009. REVIEW.


Hamby, M.E., Gragnolati, A.R., Hewett, S.J., Hewett, J.A. “TGFbeta1 and TNFalpha potentiates nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2.” Neurochem. Int. 52:962-71, 2008.

Hamby, M.E., Hewett, J.A., Hewett, S.J. “TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner.” Prostaglandins Other Lipid Mediat. 85:115-24, 2008.


Hewett, S.J., Silakova, J.M., and Hewett, J.A. “Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration.” J. Pharmacol. Exp. Ther. 319:1219-1224, 2006.

Hamby, M.E., Hewett, S.J., and Hewett, J.A. “Purification of primary astrocyte cultures: A rapid procedure for the removal of microglia.” J. Neurosci. Methods 150:128-137, 2006.

Hamby, M.E., Hewett, J.A., Hewett, S.J. “TGF-b1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2.” Glia 54:566-577, 2006.

Hewett, S.J., Bell, S.C. and Hewett, J.A. “Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system.” Pharmacol. Ther. 112:335-357, 2006. REVIEW.


Silakova, J.M., Hewett, J.A., and Hewett, S.J. Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window. J. Pharmacol. Exp. Ther. 309:1060-1066, 2004.


Hewett, S.J., Uliasz, T.F., Vidwans, A.S., and Hewett, J.A. “Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.” J. Pharmacol. Exp. Ther. 293:417-425, 2000.


Hewett, J.A., Hewett, S.J., Winkler, S., and Pfeiffer, S.E. “Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia.” J. Neurosci. Res. 56:189-198, 1999.


Hewett, J.A. and Roth, R.A. “The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria.” J. Pharmacol. Exp. Ther. 272:53-62, 1995.


Hewett, J.A., Jean, P.A., Kunkel, S.L., and Roth, R.A. “Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.” Am. J. Physiol. 265:G1011-1015, 1993.

Hewett, J.A. and Roth, R.A. “Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides.” Pharmacol. Rev. 45:382-411, 1993. REVIEW.


Hewett, J.A., Schultze, A.E., VanCise, S., and Roth, R.A. “Neutrophil depletion protects against liver injury from bacterial endotoxin.” Lab. Invest. 66:347-361, 1992.

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